Restricted Research - Award List, Note/Discussion Page
Fiscal Year: 2023
86 University of North Texas (141974)
Principal Investigator: Yang,Yong
Total Amount of Contract, Award, or Gift (Annual before 2011): $ 463,167
Exceeds $250,000 (Is it flagged?): Yes
Start and End Dates: 9/30/22 - 5/31/25
Restricted Research: YES
Academic Discipline: Biomedical Engineering
Department, Center, School, or Institute: College of Engineering
Title of Contract, Award, or Gift: Optic-nerve-head (ONH) Chips for Glaucomatous Neurodegeneration
Name of Granting or Contracting Agency/Entity:
National Institutes of Health
CFDA Link: HHS
93.867
Program Title:
none
CFDA Linked: Vision Research
Note:
The most prominent causative risk factor of glaucoma, the leading cause of irreversible blindness worldwide, is elevated intraocular pressure (IOP), which could deform the optic nerve head (ONH) and cause glaucomatous neurodegeneration. However, current glaucoma therapies that focus on lowering IOP do not stop vision loss effectively, and thus there is a pressing need to understand the mechanisms underlying glaucoma pathogenesis. In this project, we will develop a biomimetic 3-D ONH-on-a-chip system that closely mimics the key anatomical and pathophysiological characteristics of the native ONH to study astrocytic mechanisms of glaucoma pathogenesis, a missing link to develop efficacious therapies.
Discussion: No discussion notes