Restricted Research - Award List, Note/Discussion Page
Fiscal Year: 2023
109 University of North Texas (141997)
Principal Investigator: Skellam,Elizabeth Julia
Total Amount of Contract, Award, or Gift (Annual before 2011): $ 300,000
Exceeds $250,000 (Is it flagged?): Yes
Start and End Dates: 6/1/23 - 5/31/26
Restricted Research: YES
Academic Discipline: Chemistry
Department, Center, School, or Institute: College of Science
Title of Contract, Award, or Gift: Investigating the Scope and Mode of Dimerization Reactions Catalyzed by Fungal Flavin-dependent Monooxygenases
Name of Granting or Contracting Agency/Entity:
Robert A. Welch Foundation
CFDA:
Program Title: none
Note:
It is estimated that 15 - 20% of natural products are dimeric molecules arising from often unknown and unexpected enzyme catalysis. Dimerization of bioactive molecules is a simple mechanism for increasing chemical complexity, structural diversity, and inducing a more significant biological response in their target compared to the monomeric equivalent, however no widely applicable synthetic methods exist to dimerize specific monomers. Recently three flavin-dependent monooxygenases (FMOs) have been identified as catalyzing dimerization via [4+2] cycloaddition between various small molecules. Two of these FMOs are from fungi and although their function could be established in vivo, both FMOs were insoluble in vitro and therefore the precise role of the FMOs in the dimerization process could not be established. These two FMOs are not considered to be homologous as they have very low sequence identity (
Discussion: No discussion notes