Restricted Research - Award List, Note/Discussion Page
Fiscal Year: 2023
159 University of North Texas (142047)
Principal Investigator: Berman,Diana
Total Amount of Contract, Award, or Gift (Annual before 2011): $ 101,896
Exceeds $250,000 (Is it flagged?): No
Start and End Dates: 6/1/23 - 5/31/24
Restricted Research: YES
Academic Discipline: Materials Science & Engineer
Department, Center, School, or Institute: College of Engineering
Title of Contract, Award, or Gift: Collaborative Research: Combined Tribological and Bactericidal Effect of Bioinjectable Nanodiamonds on Biological Joints
Name of Granting or Contracting Agency/Entity:
National Science Foundation
CFDA Link: NSF
47.049
Program Title:
none
CFDA Linked: Mathematical and Physical Sciences
Note:
Periprosthetic infection and/or chronic inflammation caused by the formation of wear debris in the moving contact of artificial joints significantly increase the risks of joint arthroplasty procedure failure. In contrast to the natural joints, in which the initial signs of failures can be fixed by injection of hyaluronic acid, there is currently no remedy to the wear-associated degradation of the artificial joints rather than revision surgery. The long-term goal of this research is to unravel the potential of functionalized nanodiamonds (NDs) for use in lubricating artificial joints and prosthetic devices. To this end, this project focuses on understanding the fundamental interactions of NDs with artificial joint materials and biological tissues at the contact interfaces toward suppressing the movinginduced damage of joints and preventing inflammation and possible infection. The objective of this proposal is to investigate the synergy of tribological and bioactivity properties of NDs as a function of surface functionalization and ND concentration. The study will assess the mechanisms by which NDs impacted by shear stresses affect their cell cytotoxicity and antibacterial activity. Our central hypothesis is that functionalized NDs embedded in the sliding interfaces not only reduce friction and wear of contact interfaces but also subsequent inflammation and infection, thus significantly extending the lifespan of artificial joints. Our preliminary studies indicated that ND-based additives in biological fluids demonstrated a significant reduction in friction and wear of sliding titanium-titanium and titanium-plastic contacts and inhibited common bacterial growth without cytotoxicity.
Discussion: No discussion notes