Restricted Research - Award List, Note/Discussion Page
Fiscal Year: 2023
186 University of North Texas (142074)
Principal Investigator: Sprick,Justin
Total Amount of Contract, Award, or Gift (Annual before 2011): $ 56,573
Exceeds $250,000 (Is it flagged?): No
Start and End Dates: 8/1/22 - 3/31/25
Restricted Research: YES
Academic Discipline: Kinesiolgy, Hlth Promo, & Rec
Department, Center, School, or Institute: College of Education
Title of Contract, Award, or Gift: Cerebrovascular Dysregulation in Chronic Kidney Disease
Name of Granting or Contracting Agency/Entity:
American Heart Association
CFDA:
Program Title: none
Note:
Chronic Kidney Disease (CKD) patients exhibit a greater risk for cerebrovascular disease including stroke, transient ischemic attack, and cerebral small vessel disease. In addition, CKD patients who do experience a stroke suffer from higher mortality rates and poorer recovery. Despite this elevated risk for cerebrovascular disease, mechanisms governing cerebral blood flow regulation in CKD are poorly understood. This knowledge gap is critical because impairments in cerebrovascular regulatory mechanisms predict stroke in other high-risk populations. This project will explore two potential mechanisms that may contribute to the elevated cerebrovascular disease burden experienced by CKD patients: 1) impaired cerebrovascular dilatory ability and 2) impaired cerebral autoregulation. Both of these indices are well-recognized biomarkers of cerebrovascular function but have not been explored in CKD. We will compare these indices between CKD patients and matched controls without CKD to determine which specific pathways become dysregulated in CKD. Additionally, we will determine if these two indices can be improved through regular aerobic exercise training, consisting of moderate-to vigorous cycling exercise, performed 3 days a week over a period of 12 weeks. We will compare changes in cerebrovascular dilatory ability and cerebral autoregulation following the intervention to a control group performing stretching and balance exercise over the same 12 week period. Collectively, these studies will provide new insight into the pathophysiology underlying cerebrovascular disease risk in CKD so that targeted treatments may be developed to ameliorate this dysfunction.
Discussion: No discussion notes