Restricted Research - Award List, Note/Discussion Page
Fiscal Year: 2023
321 The University of Texas Rio Grande Valley (142209)
Principal Investigator: Tripathi,Manish Kumar
Total Amount of Contract, Award, or Gift (Annual before 2011): $ 149,985
Exceeds $250,000 (Is it flagged?): No
Start and End Dates: 11/1/22 - 10/31/25
Restricted Research: YES
Academic Discipline: Immunology and Microbiology
Department, Center, School, or Institute: Immunology and Microbiology
Title of Contract, Award, or Gift: LncRNA Malat1 as a potential therapeutic target for Alzheimer’s Disease
Name of Granting or Contracting Agency/Entity:
The Alzheimer's Association
CFDA: n/a
Program Title: n/a
Note:
SAMs 1.1.1--LncRNAs act as part of noncoding RNAs at high levels of complex and stimulatory configurations in basic molecular mechanisms. Their extensive regulatory activity in the CNS continues on a small scale, from the functions of synapses to large-scale neurodevelopment and cognitive functions, aging, and can be seen in both health and disease situations. One of the vast consequences of the pathological role of dysregulated lncRNAs in the CNS due to their role in a network of regulatory pathways can be manifested in Alzheimer's as a neurodegenerative disease. In our preliminary studies, we have found reduced lncRNA MALAT1 expression in the brains of AD patients. However, the role of lncRNA MALAT1 in AD is limited in knowledge, and no previous studies have attempted to elucidate the mechanism of MALAT1 in AD progression. Therefore, we propose an animal model (5xFAD) and various cell lines to study the mechanistic role of lncRNA MALAT1 in the pathogenesis of Alzheimer's disease.
Discussion: No discussion notes