Restricted Research - Award List, Note/Discussion Page
Fiscal Year: 2023
344 The University of Texas Rio Grande Valley (142232)
Principal Investigator: Biguetti,Claudia Cristina
Total Amount of Contract, Award, or Gift (Annual before 2011): $ 30,000
Exceeds $250,000 (Is it flagged?): No
Start and End Dates: 1/1/23 - 12/31/23
Restricted Research: YES
Academic Discipline: School of Podiatric Medicine
Department, Center, School, or Institute: School of Podiatric Medicine
Title of Contract, Award, or Gift: CTSA T&E Pilot Award: Immunological Blood Biomarkers and Oral Microbiome in theProgression of Type II Diabetes: A Pilot Study in Mexican American Cohort from Rio Grande Valley
Name of Granting or Contracting Agency/Entity:
Univ of TX Health Scien Centr at Houston
CFDA: 93.35
Program Title: National Center for Advancing Translational Sciences
Note:
SAMs- 1.1.1 This project has an approved IRB. The host immune system and microbiome influence one another to maintain tissue homeostasis, while a dysbiosis may lead to a dysregulation of immunity and increased susceptibility to infection and metabolic syndrome1. Dysregulation in host-microbiome has been suggested as a critical risk factor for development of pre-diabetes and type 2 diabetes (T2D), with particular attention directed towards gut microbiota2-5. However, the oral cavity represents the second most abundant microbiota in humans, and it has been linked to rheumatoid arthritis, systemic inflammation, cardiovascular disease, andT2D6-9. Periodontopathogenic bacteria, such asP.gingivalis and A. actinomycetemcomitans, which are involved in destructive inflammation and bone loss, seem to be directly related to poor glycemic control and increased T2D risk10-13. A recent publication from the ongoing "The Diabetes Prevention Microbiome Study", (IRB: HSC-SPH-06-0225), performed in a Mexican American population from Starr County (Rio Grande Valley, Texas), demonstrated that diabetes status impacts the IgA+-microbiome in saliva2, while a subsequent study revealed an immunodysregulation linked to the imbalance of local Th17 and Tregs in gut/salivary samples in the same cohort8. However, the overall relationship between TD2 diabetesprogression and host immunity imbalance inMexican-Americans requires mechanistic studies, and its possibleassociation with changes in oral microbiome and inflammatory complications in advanced T2D stages (limb amputations) remains to be determined.
Discussion: No discussion notes