Restricted Research - Award List, Note/Discussion Page
Fiscal Year: 2023
738 Prairie View A&M University (142626)
Principal Investigator: Abdelwahed, Sameh
Total Amount of Contract, Award, or Gift (Annual before 2011): $ 8,160
Exceeds $250,000 (Is it flagged?): No
Start and End Dates: 9/1/22 - 8/31/23
Restricted Research: YES
Academic Discipline: Chemistry
Department, Center, School, or Institute: Chemistry
Title of Contract, Award, or Gift: Exploiting B1 Vitamin as a delivery vehicle for cargo inside the living cell
Name of Granting or Contracting Agency/Entity:
Tertiary Education Trust Fund
CFDA: n/a
Program Title: none
Note:
1.1.1. Within the cell, the active metabolites will be cleaved via enzymes present within the bacterial cell, releasing drug from thiamin. Drug will perform its desired function while thiamin will keep the thiamin biosynthetic machinery shut by binding to riboswitch (Fig. 1). This proposal advances the use of the essential micronutrient, thiamin, as a transporter for drug delivery of active metabolites to the specific target site.
Discussion: No discussion notes