Restricted Research - Award List, Note/Discussion Page
Fiscal Year: 2023
895 Texas Tech University (142783)
Principal Investigator: Hong, Zhongkui
Total Amount of Contract, Award, or Gift (Annual before 2011): $ 338,992
Exceeds $250,000 (Is it flagged?): Yes
Start and End Dates: 1/6/23 - 1/31/24
Restricted Research: YES
Academic Discipline: Mechanical Engineering
Department, Center, School, or Institute: Mechanical Engineering
Title of Contract, Award, or Gift: Mechanical Response and Cytoskeletal Rearrangement Following Interrupted cholesterol Metabolism in Vascular Smooth Muscle Cell
Name of Granting or Contracting Agency/Entity:
DHHS - NIH
CFDA Link: HHS
93.837
Program Title:
n/a
CFDA Linked: Heart and Vascular Diseases Research
Note:
1.1.1: In normal arteries, vascular smooth muscle cells (VSMCs) reside in and attach to vascular wall matrix proteins in the middle layer of artery wall; during atherosclerosis, VSMCs migrate into the innermost layer of the arterial wall and participate in plaque formation. Our research aims to understand the mechanisms of this process, specifically by examining how cholesterol and matrix stiffness alters the attachment of VSMCs to vascular wall structural proteins and affects the migration of VSMCs during the development of atherosclerosis. With the knowledge obtained in this study, we anticipate moving closer to designing therapeutic treatments targeting more specific adhesion molecules of VSMCs to prevent, arrest, and/or reverse the process of atherosclerosis.
Discussion: No discussion notes