Restricted Research - Award List, Note/Discussion Page
Fiscal Year: 2023
1135 University of Houston (143023)
Principal Investigator: McKeon,Frank D
Total Amount of Contract, Award, or Gift (Annual before 2011): $ 4,690,920
Exceeds $250,000 (Is it flagged?): Yes
Start and End Dates: 9/15/22 - 8/31/27
Restricted Research: YES
Academic Discipline: Biology and Biochemistry
Department, Center, School, or Institute: Biology and Biochemistry
Title of Contract, Award, or Gift: COMMON STEM CELL OF ORIGIN FOR JUNCTIONAL AND GASTRIC ADENOCARCINOMA
Name of Granting or Contracting Agency/Entity:
National Cancer Institute
CFDA Link: HHS
93.396
Program Title:
n/a
CFDA Linked: Cancer Biology Research
Note:
We will 1) use similar methods to clone the intrinsic IM stem cells from human fetal and adult GE junctions and gastric mucosa; 2) engineer mouse models for conditional expression of oncogenic factors in intrinsic IM cells; and 3) identify small molecules that selectively target intrinsic IM stem cells as leads for therapeutics to prevent EAC and iGC. SAMs 1.1.1
Discussion: No discussion notes