Restricted Research - Award List, Note/Discussion Page
Fiscal Year: 2023
1148 University of Houston (143036)
Principal Investigator: Patel,Nimesh Bhikhu
Total Amount of Contract, Award, or Gift (Annual before 2011): $ 2,090,272
Exceeds $250,000 (Is it flagged?): Yes
Start and End Dates: 8/1/22 - 5/31/26
Restricted Research: YES
Academic Discipline: Optometry
Department, Center, School, or Institute: Optometry Vision Sciences
Title of Contract, Award, or Gift: OCTA PERFUSED VASCULAR VOLUME AND GLAUCOMA PROGRESSION IN THE NON-HUMAN PRIMATE
Name of Granting or Contracting Agency/Entity:
National Eye Institute
CFDA Link: HHS
93.867
Program Title:
n/a
CFDA Linked: Vision Research
Note:
We will determine; 1. if the rate of disease progression is related to baseline global and regional measures of vascular volume / volume density and regional OCTA temporal variability, 2. if there is loss of vascular volume prior to inner retinal thickness, 3. if the rate of structural and functional changes are is related to the extent to which vascular perfusion changes with IOP challenge, and 4. using post-mortem tissue, define vascular anatomy (pericyte coverage, endothelial cell density, capillary basement membrane thickness/integrity) in healthy and disease eyes and association with in vivo OCTA measures. Overall, the results from these studies will establish if vascular measures as quantified using OCTA can be used to determine risk of pathology, and rate of glaucoma progression. SAMs 1.1.1
Discussion: No discussion notes