Restricted Research - Award List, Note/Discussion Page
Fiscal Year: 2023
1166 University of Houston (143054)
Principal Investigator: Chen,Tai-Yen
Total Amount of Contract, Award, or Gift (Annual before 2011): $ 979,019
Exceeds $250,000 (Is it flagged?): Yes
Start and End Dates: 4/15/23 - 3/31/28
Restricted Research: YES
Academic Discipline: Chemistry
Department, Center, School, or Institute: Chemistry
Title of Contract, Award, or Gift: CAREER: OLIGOMERIC STOICHIOMETRY OF SUPEROXIDE DISMUTASE 1 AND NEURONAL ANTIOXIDANT DEFENSE
Name of Granting or Contracting Agency/Entity:
National Science Foundation
CFDA Link: NSF
47.074
Program Title:
n/a
CFDA Linked: Biological Sciences
Note:
Our main research objective is to develop an innovative single-molecule methodology to define how neurons modulate oligomerizations of Cu/Zn superoxide dismutase (SOD1), the frontline antioxidant protein, in response to environmental stressors for neuronal antioxidant defense. Particular emphasis will be placed on the "in-cell quantification of protein oligomer distributions". All experiments will be conducted using homozygous knock-in human embryonic stem cell-derived neurons, ensuring that our results are physiologically relevant and reflect the native mechanisms of neuronal antioxidant defense. SAMs 1.1.3
Discussion: No discussion notes