Restricted Research - Award List, Note/Discussion Page
Fiscal Year: 2023
1227 University of Houston (143115)
Principal Investigator: Hao,Jiukuan
Total Amount of Contract, Award, or Gift (Annual before 2011): $ 439,900
Exceeds $250,000 (Is it flagged?): Yes
Start and End Dates: 6/15/23 - 6/30/25
Restricted Research: YES
Academic Discipline: Pharmacy
Department, Center, School, or Institute: Pharmacological and Pharmaceutical Sciences
Title of Contract, Award, or Gift: A NOVEL-DESIGNED SULFONYLUREA COMPOUND FOR VASCULAR DEMENTIA THERAPY
Name of Granting or Contracting Agency/Entity:
National Institute of Neurological
CFDA Link: HHS
93.853
Program Title:
n/a
CFDA Linked: Extramural Research Programs in the Neurosciences and Neurological Disorders
Note:
This proposal is proposed to investigate therapeutic effects and elucidate its mechanism of action using vascular dementia model in mouse. Our goal is to develop a lead molecule for NLRP3 inhibition with high selectivity, adequate metabolic stability, and low toxicity that can be used to improve cognitive outcomes of vascular dementia. SAMs 1.1.1
Discussion: No discussion notes