Restricted Research - Award List, Note/Discussion Page
Fiscal Year: 2023
1358 University of Houston (143246)
Principal Investigator: Boini,Krishna M
Total Amount of Contract, Award, or Gift (Annual before 2011): $ 102,230
Exceeds $250,000 (Is it flagged?): No
Start and End Dates: 8/19/22 - 6/30/23
Restricted Research: YES
Academic Discipline: Pharmacy
Department, Center, School, or Institute: Pharmacological and Pharmaceutical Sciences
Title of Contract, Award, or Gift: ROLE OF TRIMETHYLAMINE-N-OXIDE IN ENDOTHELIAL DYSFUNCTION
Name of Granting or Contracting Agency/Entity:
Arkansas Colleges of Health Education
CFDA Link: HHS
93.837
Program Title:
n/a
CFDA Linked: Heart and Vascular Diseases Research
Note:
Specific Aim 1: To address how TMAO-induced Nlrp3 inflammasome activation contributes to endothelial dysfunction and atherosclerosis in in vivo using Nlrp3-/- mice, endothelium-specific Nlrp3 knockout mice (EC-Nlrp3-/-) and their wild type littermates; Specific Aim 2: To investigate how the non-inflammatory effects of TMAO activated Nlrp3 inflammasomes contributes to impaired endothelium dependent vasodilation, pyroptosis and DAMPs production in primary cultures of CAECs, Nlrp3-/- and Nlrp3+/+ mice; Specific Aim 3: To determine whether TMAO stimulates the formation of MVBs containing NRLP3 inflammasome products in in vitro or in vivo endothelial cells to release exosomes and whether these inflamed exosomes induce endothelial dysfunction and vascular injury. SAMs 1.1.1
Discussion: No discussion notes