Restricted Research - Award List, Note/Discussion Page
Fiscal Year: 2023
1403 University of Houston (143291)
Principal Investigator: Wu,Mingfu
Total Amount of Contract, Award, or Gift (Annual before 2011): $ 65,106
Exceeds $250,000 (Is it flagged?): No
Start and End Dates: 1/1/23 - 12/31/24
Restricted Research: YES
Academic Discipline: Pharmacy
Department, Center, School, or Institute: Pharmacological and Pharmaceutical Sciences
Title of Contract, Award, or Gift: NFPS REGULATE CARDIAC FIBROBLASTS DIFFERENTIATION DURING DEVELOPMENT AND FIBROSIS IN AGING AND INJURED HEARTS
Name of Granting or Contracting Agency/Entity:
American Heart Association - National
CFDA: 00.000
Program Title: n/a
Note:
There is a cell type in our body (fibroblasts) which cause this disease when any injury occurs to heart. The treatment for this disease is under research. There is an essential protein family in our body, called Numb Family protein (NFPs). This protein is important for heart formation. But, whether this protein has any role in fibrosis disease is not known. We will see if this protein family controls this cell formation in heart when a baby grows up inside the mother's body during pregnancy. This will tell us if we can make any medicine using this protein to treat any disease caused by this cell. We will also study if this protein can control fibrosis disease when we grow old. We will also observe if this protein can control fibrosis disease when any injury happens to heart. This will tell us if findings from this study can be used to make medicine to treat fibrosis disease, when we grow old. This will inform us if the findings can be used to make medicine to treat fibrosis disease, when any injury happens to heart. We will use mouse as models for this study. The result we get using mouse models can be used to treat fibrosis in human body. SAMs 1.1.1
Discussion: No discussion notes