Restricted Research - Award List, Note/Discussion Page
Fiscal Year: 2023
1419 University of Houston (143307)
Principal Investigator: Sun,Rongjin
Total Amount of Contract, Award, or Gift (Annual before 2011): $ 49,998
Exceeds $250,000 (Is it flagged?): No
Start and End Dates: 6/1/23 - 5/31/24
Restricted Research: YES
Academic Discipline: Pharmacy
Department, Center, School, or Institute: Pharmacological and Pharmaceutical Sciences
Title of Contract, Award, or Gift: DETERMINATION OF INTESTINAL EXCRETION OF GILEAD RESEARCH COMPOUNDS USING A WELL-CHARACTERIZED MODIFIED PERFUSED RAT INTESTINAL MODEL
Name of Granting or Contracting Agency/Entity:
Gilead Sciences, Inc
CFDA: 00.000
Program Title: n/a
Note:
We have the following three Specific Aims: 1. To determine the intestinal excretion characteristics of Gilead-20 using the modified perfused rat intestinal model. 2. To determine the impact of efflux transporters in intestinal excretion of apixaban by oral administration using the modified in situ perfusion model. 3. To determine the effect of P-gp inducers on intestinal and liver P-gp mRNA and protein total expression, and intestinal excretion. SAMs 1.1.1 and 1.1.3
Discussion: No discussion notes