Restricted Research - Award List, Note/Discussion Page
Fiscal Year: 2023
1792 The University of Texas at El Paso (143680)
Principal Investigator: Lu,Weiqin
Total Amount of Contract, Award, or Gift (Annual before 2011): $ 690,750
Exceeds $250,000 (Is it flagged?): Yes
Start and End Dates: 9/1/22 - 5/31/25
Restricted Research: YES
Academic Discipline: Pharmaceutical Science
Department, Center, School, or Institute: Pharmaceutical Science
Title of Contract, Award, or Gift: R01: Unraveling the Role of NADPH Oxidase in Inflammation-associated Pancreatic Diseases
Name of Granting or Contracting Agency/Entity:
NIH - NATL INST OF DIABETES & DIG & K D
CFDA Link: HHS
93.847
Program Title:
Diabetes, Digestive, and Kidney Diseases Extramural Research
CFDA Linked: Diabetes, Endocrinology and Metabolism Research
Note:
RO1 Our studies support the role of inflammatory stimulants in promoting mutant KRAS hyperactivation leading to a long-sustained pancreatic inflammation, irreversible acinar-to-ductal metaplasia, and pancreatic intraepithelial neoplasia. The objective of this proposal is to unravel the role of NADPH oxidases as a critical mediator linking inflammation to mutant KRAS hyperactivation and associated pathologic consequences. Knowledge gained from the current proposal will guide the design of new targets for prevention and treatment in humans of inflammation- associated pancreatic diseases.
Discussion: No discussion notes