Restricted Research - Award List, Note/Discussion Page
Fiscal Year: 2023
1796 The University of Texas at El Paso (143684)
Principal Investigator: ODell,Laura E
Total Amount of Contract, Award, or Gift (Annual before 2011): $ 615,055
Exceeds $250,000 (Is it flagged?): Yes
Start and End Dates: 7/5/22 - 6/30/26
Restricted Research: YES
Academic Discipline: Psychology
Department, Center, School, or Institute: Psychology
Title of Contract, Award, or Gift: R16 SURE: PREVENTATIVE BIOMARKERS AND POTENTIAL PHARMACOTHERAPIES FOR NICOTINE USE AND DIABETES
Name of Granting or Contracting Agency/Entity:
NIH - NATL INST OF GEN MEDICAL SCIENCES
CFDA Link: HHS
93.859
Program Title:
Biomedical Research and Research Training
CFDA Linked: Biomedical Research and Research Training
Note:
Persons with diabetes are more susceptible to smoking and the long-term health complications associated with chronic nicotine use. The proposed team of neuroscientists employ rodent models to provide a better understanding of the mechanisms that promote nicotine use in persons with diabetes. Aim 1 will assess the development of insulin resistance and escalation of nicotine self-administration in female and male rats. Aim 2 will assess whether administration of various pharmacotherapies for diabetes (Insulin, Exenatide, Metformin, and Cycloset) or smoking cessation (Wellbutrin and Chantix) alters the trajectory of the same measures collected in Aim 1 using both Type 1 and Type 2 rodent models of diabetes. The scientific premise is that the development of insulin resistance will predict escalation of the reinforcing effects of nicotine in both types of diabetic rats. We anticipate that insulin-dependent female rats will display the highest nicotine intake, particularly during abstinence periods. Also, it is expected that pharmacological interventions that prevent the development of insulin resistance will diminish the strong rewarding effects of nicotine observed in diabetic rats. These studies are rigorous because they will utilize rodent models of Type 1 and Type 2 diabetes to examine time-dependent changes in the reinforcing effects of nicotine using extended self-administration procedures developed in our laboratory.
Discussion: No discussion notes