Restricted Research - Award List, Note/Discussion Page
Fiscal Year: 2023
1799 The University of Texas at El Paso (143687)
Principal Investigator: Han,Kyung-An
Total Amount of Contract, Award, or Gift (Annual before 2011): $ 608,000
Exceeds $250,000 (Is it flagged?): Yes
Start and End Dates: 5/13/22 - 4/30/26
Restricted Research: NO
Academic Discipline: Biological Sciences
Department, Center, School, or Institute: Biological Sciences
Title of Contract, Award, or Gift: SURE: Genetic dissection of dementia
Name of Granting or Contracting Agency/Entity:
NIH - NATL INST OF GEN MEDICAL SCIENCES
CFDA Link: HHS
93.859
Program Title:
Biomedical Research and Research Training
CFDA Linked: Biomedical Research and Research Training
Note:
Alzheimer's disease (AD) and related dementias are chronic and progressive diseases without cure. They affect over 6 million elderly Americans and a larger number of caregivers, imposing a huge health economic burden. To develop effective strategies to combat these devastating diseases, we need to better understand the genes and mechanisms causing dementia. The genetic mutations causing dementia are identified but account for only a small subset. Genome wide association studies (GWAS) identified many genetic loci linked to dementia but they are often in introns or intergenic regions, making it difficult to validate how they affect gene expression/ function or which genes are affected, respectively. At present, the functional contribution of most GWAS loci to dementia is not substantiated. We address this knowledge gap in Drosophila, in which the flies with mutations [deficiency (Df)/deletion, insertion or point mutation] in most genes are already available, and the expression and function of most genes can be readily manipulated via transgenic expression, RNA interference (RNAi) or etc. It is highly feasible in Drosophila to study the functional contribution to dementia of all genes. To this end, the major goal of this research is to discover the genes functionally contributing to dementia using innovative strategies.
Discussion:
Withdrawn by Institution (Manuela Dokie) - Previously reported in 2022.