Restricted Research - Award List, Note/Discussion Page
Fiscal Year: 2023
1807 The University of Texas at El Paso (143695)
Principal Investigator: Koculi,Eda
Total Amount of Contract, Award, or Gift (Annual before 2011): $ 599,113
Exceeds $250,000 (Is it flagged?): Yes
Start and End Dates: 6/1/22 - 3/31/24
Restricted Research: YES
Academic Discipline: Chemistry
Department, Center, School, or Institute: Chemistry
Title of Contract, Award, or Gift: Studies of Ribosome Biogenesis
Name of Granting or Contracting Agency/Entity:
NIH - NATL INST OF GEN MEDICAL SCIENCES
CFDA Link: HHS
93.859
Program Title:
Biomedical Research and Research Training
CFDA Linked: Biomedical Research and Research Training
Note:
According to World Health Organization, pathogenic resistant bacteria are one of the greatest threats to humanity; hence, novel broad range antibiotics are of great public health interest. The ribosome structure is highly conserved in bacteria suggesting that the structure and the physical properties of the intermediates in the assembly pathway are also conserved. The insights obtained from the experiments outlined in this proposal on the molecular structure and physical properties of the intermediates in the Escherichia coli ribosome assembly pathway could guide the design of novel broad range classes of antibiotics, which would kill pathogenic bacteria by preventing the formation of the properly assembled ribosomes.
Discussion: No discussion notes