Restricted Research - Award List, Note/Discussion Page
Fiscal Year: 2023
1898 The University of Texas at El Paso (143786)
Principal Investigator: Kirken,Robert A
Total Amount of Contract, Award, or Gift (Annual before 2011): $ 147,840
Exceeds $250,000 (Is it flagged?): No
Start and End Dates: 6/8/22 - 2/29/24
Restricted Research: NO
Academic Discipline: Border Biomedical Research Ctr
Department, Center, School, or Institute: Border Biomedical Research Ctr
Title of Contract, Award, or Gift: Supplement: The impact of diet on the therapeutic, rewarding and adverse effects of morphine
Name of Granting or Contracting Agency/Entity:
NIH - NATL INST ON MINORITY HEALTH & H D
CFDA Link: HHS
93.307
Program Title:
Minority Health and Health Disparities Research
CFDA Linked: Minority Health and Health Disparities Research
Note:
Opioid use disorder (OUD) is a major public health concern contributing to approximately 68% of all drug overdose deaths in the United States. Opioid drugs, including morphine, heroin, oxycodone, codeine and fentanyl) are a group of drugs that are sometimes used medicinally for pain relief, but that also have abuse liability and can lead to OUD. As OUD rates in the U.S. continue to rise, another simultaneous public health crisis is the obesity epidemic. Obesity is sometimes the result of the overconsumption of high fat foods, combined with genetic and other environmental factors. Work from our lab and others suggests that eating a high fat diet, even in the absence of weight gain or obesity, can lead to changes in drug sensitivity that might impact medication effectiveness, side effect probability and abuse vulnerability. In contrast, some high fat diets that are low in carbohydrates (e.g., ketogenic diets) are potentially beneficial for some health outcomes and have been explored as a potential intervention for obesity and weight loss. The goal of this pilot project is to evaluate the effect of dietary history (with a traditional high fat or a ketogenic diet) on sensitivity of rats to the therapeutic and adverse effects of morphine following acute and chronic exposure. Chronic exposure to opioid pain-relieving drugs is common among patients with chronic pain, and can result in tolerance (e.g., reduced antinociceptive effectiveness over time) as well as dependence (as demonstrated by the appearance of symptoms of withdrawal following the suspension of chronic administration).
Discussion:
Withdrawn by Institution (Manuela Dokie) - Previously reported in 2022.