Restricted Research - Award List, Note/Discussion Page
Fiscal Year: 2023
2079 The University of Texas at Dallas (143967)
Principal Investigator: Ding,Yichen
Total Amount of Contract, Award, or Gift (Annual before 2011): $ 1,883,456
Exceeds $250,000 (Is it flagged?): Yes
Start and End Dates: 4/15/23 - 3/31/28
Restricted Research: YES
Academic Discipline: Bioengineering
Department, Center, School, or Institute: ECS
Title of Contract, Award, or Gift: Volumetric Imaging and Computation to Characterize Cardiac Electromechanical Coupling
Name of Granting or Contracting Agency/Entity:
Natl Institutes of Health
CFDA Link: HHS
93.837
Program Title:
none
CFDA Linked: Heart and Vascular Diseases Research
Note:
We will test the hypothesis that small molecule-induced bradycardia activates distinct EC coupling abnormalities responsible for various arrhythmias. In Aim 1, we will reveal the 4D calcium activities across the intact heart with high spatiotemporal resolution via our custom-built structured-illumination light-field microscope. In Aim 2, we will elucidate the electromechanical interaction among neighboring cardiomyocytes during 5~10 cardiac cycles. In Aim 3, we will assess the excitation-contraction coupling abnormalities induced by small molecule compounds. In this context, success of this research will establish a new holistic strategy to in vivo investigate sophisticated electromechanical interaction, providing an entry point to further study the underlying mechanism of arrhythmias and prospectively identify arrhythmogenic compounds.
Discussion: No discussion notes