Restricted Research - Award List, Note/Discussion Page
Fiscal Year: 2023
2080 The University of Texas at Dallas (143968)
Principal Investigator: Rodrigues,Danieli Balbueno C
Total Amount of Contract, Award, or Gift (Annual before 2011): $ 1,852,500
Exceeds $250,000 (Is it flagged?): Yes
Start and End Dates: 9/1/22 - 8/31/27
Restricted Research: YES
Academic Discipline: Bioengineering
Department, Center, School, or Institute: ECS
Title of Contract, Award, or Gift: Multifunctional Ionic Liquid Application for Treatment of Peri-implant Diseases
Name of Granting or Contracting Agency/Entity:
Natl Institutes of Health
CFDA Link: HHS
93.121
Program Title:
none
CFDA Linked: Oral Diseases and Disorders Research
Note:
In Aim 1, a standard method for application of IonL-Phe will be determined based on release kinetic studies and its effect on detoxified Ti surface properties. In Aim 2, an in vitro evaluation of IonL-Phe application on plasma protein deposition and subsequent effect on mammalian cell growth under bacterial challenge or multispecies bacterial adhesion on detoxified Ti will be performed. In Aim 3, the in vivo impact of IonL-Phe application on protein layer formation, host tissue re-integration with Ti implant surface, and oral microbiome composition will be assessed after induction of PI diseases in a rat model.
Discussion: No discussion notes