Restricted Research - Award List, Note/Discussion Page
Fiscal Year: 2023
2081 The University of Texas at Dallas (143969)
Principal Investigator: Thorn,Catherine A
Total Amount of Contract, Award, or Gift (Annual before 2011): $ 1,675,148
Exceeds $250,000 (Is it flagged?): Yes
Start and End Dates: 1/15/23 - 11/30/27
Restricted Research: YES
Academic Discipline: Neuroscience
Department, Center, School, or Institute: BBS
Title of Contract, Award, or Gift: Peripheral Nerve Stimulation for Activation of Dopaminergic Nuclei
Name of Granting or Contracting Agency/Entity:
Natl Institutes of Health
CFDA Link: HHS
93.853
Program Title:
none
CFDA Linked: Extramural Research Programs in the Neurosciences and Neurological Disorders
Note:
Understanding whether and how lateralized vagal stimulation differentially activates reward networks is crucial for further clinical development of therapeutic technology. Left cervical VNS is currently FDA approved for the treatment of epilepsy and major depressive disorders, and is rapidly emerging as a treatment to promote weight loss, extinction of drug seeking, and motor rehabilitation after neural injuries. Importantly, the effectiveness of VNS over this expanded set of therapeutic indications depends on optimal activation of the dopaminergic pathways known to support reward-related reinforcement of learned behaviors. Thus, targeted modulation of these pathways could provide additional mechanisms to induce therapeutic neuroplasticity within the motor system.
Discussion: No discussion notes