Restricted Research - Award List, Note/Discussion Page
Fiscal Year: 2023
2297 The University of Texas at San Antonio (144185)
Principal Investigator: Macpherson, Lindsey
Total Amount of Contract, Award, or Gift (Annual before 2011): $ 780,000
Exceeds $250,000 (Is it flagged?): Yes
Start and End Dates: 9/1/23 - 8/31/28
Restricted Research: YES
Academic Discipline: VPREDKE
Department, Center, School, or Institute: Brain Health Consortium
Title of Contract, Award, or Gift: Comprehensive functional phenotyping of trigeminal neurons innervating temporomandibular joint masticatory structures in male, female and aged mice, primates, and humans with and without myalgia
Name of Granting or Contracting Agency/Entity:
University of Texas Health Science Center San Antonio
CFDA Link: HHS
93.846
Program Title:
none
CFDA Linked: Arthritis, Musculoskeletal and Skin Diseases Research
Note:
SAMs 1.1.1; The objectives of this research project are to comprehensively elucidate function, distribution, and plasticity of trigeminal (TG) neurons innervating masseter muscle (MM), tendon, and fascia in male, female and aged mice, primates and humans with the presence or absence of TMDM. In support of this, our published and preliminary data demonstrate that: (1) MM structure is innervated by TG neurons with distinct electrophysiological properties; (2) MM in mice and primate is innervated always exclusively by myelinated A-fibers; and (3) according to single-cell seq results MM in mice is innervated by TG neurons with unique molecular signatures. Moreover, our multi-disciplinary team has shown feasibility for (1) high-precision and resolution single cell sequencing approaches, (2) 3D-mapping of afferent fibers in tissues; (3) in vivo characterization of MM innervating TG neurons; (4) work with primate and human patient tissues, (5) the development of clinically relevant TMDM models and (6) data harmonization, integration, and visualization. Taken together, we anticipate that this project will elucidate maps with the location, phenotype and plasticity for TG neurons innervating MM structure in male, female and aged mice, primates and humans with the presence or absence of TMDM. Additionally, we expect target identification in humans for new treatments of TMDM.
Discussion: No discussion notes