Restricted Research - Award List, Note/Discussion Page
Fiscal Year: 2023
2336 The University of Texas at San Antonio (144224)
Principal Investigator: Romero Uribe, Gabriela
Total Amount of Contract, Award, or Gift (Annual before 2011): $ 390,500
Exceeds $250,000 (Is it flagged?): Yes
Start and End Dates: 1/1/21 - 12/31/22
Restricted Research: YES
Academic Discipline: Engineering
Department, Center, School, or Institute: CEID Biomed Eng Chem Eng
Title of Contract, Award, or Gift: Non-invasive, Transgene-free, on-demand Pharmacological Modulation of Neural Activity
Name of Granting or Contracting Agency/Entity:
National Institute of Neurological Disorders and Stroke (NINDS)
CFDA Link: HHS
93.853
Program Title:
none
CFDA Linked: Extramural Research Programs in the Neurosciences and Neurological Disorders
Note:
SAMs 1.1.1 This research project will develop a novel wireless pharmacological brain modulation approach that depends on MNPs heating effects to release neuromodulatory compounds from temperature-sensitive polymers grafted on the surface of MNPs. Additionally, we will fabricate a nanoconjugate composed of surface engineered MNPs and gold nanorods (GNRs) for photoacoustic tomography (PAT)-guided, magnetothermally-controlled release of neuromodulatory compounds. This research project drives new advances in stimuli-responsive hybrid nanoparticle systems for personalized pharmacological modulation of neural activity. Finally, the functional properties of clinically-relevant neural modulation by magnetothermal drug release will be evaluated through in vitro models and rat brains.
Discussion: No discussion notes