Restricted Research - Award List, Note/Discussion Page
Fiscal Year: 2023
2413 The University of Texas at San Antonio (144301)
Principal Investigator: Meyer-Acosta, Karina
Total Amount of Contract, Award, or Gift (Annual before 2011): $ 116,805
Exceeds $250,000 (Is it flagged?): No
Start and End Dates: 5/30/23 - 5/30/26
Restricted Research: YES
Academic Discipline: VPREDKE
Department, Center, School, or Institute: Brain Health Consortium
Title of Contract, Award, or Gift: Modeling Alzheimer's disease in Hispanic Latino populations using human cortical organoids
Name of Granting or Contracting Agency/Entity:
National Institute on Aging (NIA) - NIH
CFDA Link: HHS
93.213
Program Title:
none
CFDA Linked: Research and Training in Complementary and Alternative Medicine
Note:
SAMs 1.1.1 and 1.3.2; In this research project, the central hypothesis is that HMA background modulates the APOE independent of genotype to protect against Alzheimer 's Disease(AD)-related phenotypes. Since AD develops decades before cognitive decline and ethnic variation is human-specific, the fellow will test my hypothesis in 3D cortical organoid. They will 1) Characterize the effect of APOE4 on AD-related cellular phenotypes with WNH background, and 2) determine the effect of HMA background on APOE4 mediated phenotypes and gene transcription. Under this fellowship, the fellow will continue their training to expand their molecular toolkit and in vitro disease modeling, honing their skills as a molecular neuroscientist. This fellow will also strengthen analytical skills and learn new methods to probe gene expression by training under her sponsor and a supporting group of scientists.
Discussion: No discussion notes