Restricted Research - Award List, Note/Discussion Page
Fiscal Year: 2023
2449 The University of Texas at San Antonio (144337)
Principal Investigator: Soshnev, Alexey
Total Amount of Contract, Award, or Gift (Annual before 2011): $ 75,000
Exceeds $250,000 (Is it flagged?): No
Start and End Dates: 9/1/22 - 7/31/23
Restricted Research: YES
Academic Discipline: SCIENCES
Department, Center, School, or Institute: Cos Neurosci Dev & Regen Bio
Title of Contract, Award, or Gift: Role of novel onco-histone mutations in B-cell malignancies
Name of Granting or Contracting Agency/Entity:
Weill Cornell Medical College
CFDA: 0
Program Title: none
Note:
SAMs 1.1.1; The goal of the research is to reveal the contributions of linker histones to the humoral response and lymphomagenesis from both biochemical and biological perspectives. We will achieve through the following specific aims: 1) Determine the role and mechanism through which H1 is required to the GC reaction; 2) Determine the mechanism through which H1 mutations reprogram the epigenome drive lymphomagenesis; and 3) Determine whether and how H1 soforms function as bona fide lymphoma suppressors. The study of H1 is quite challenging, but we are uniquely poised to unravel GC canonical l in the molecular details and functional consequences of H1mutations in lymphoid carcinogenesis by bringing together leaders in the field of transcriptional regulation, chromatin, epigenetic regulation and lymphomagenesis.
Discussion: No discussion notes