Restricted Research - Award List, Note/Discussion Page
Fiscal Year: 2023
2458 The University of Texas at San Antonio (144346)
Principal Investigator: Carless,Melanie
Total Amount of Contract, Award, or Gift (Annual before 2011): $ 57,290
Exceeds $250,000 (Is it flagged?): No
Start and End Dates: 7/1/20 - 6/30/21
Restricted Research: YES
Academic Discipline: Neurosciences
Department, Center, School, or Institute: COS NEUROSCI DEV & REGEN BIO
Title of Contract, Award, or Gift: Epigenomics of Cardiometabolic Diseases in Mexican Americans - 000509019-SC002
Name of Granting or Contracting Agency/Entity:
University of Alabama
CFDA Link: HHS
93.837
Program Title:
none
CFDA Linked: Heart and Vascular Diseases Research
Note:
SAMs 1.1.1 The goals of this research project include three specific aims to be carried out in the San Antonio Family Heart Study (SAFHS) cohort of 600 Mexican Americans: 1) To determine the association of quantitative methylation data from ABCG1, CPT1A, and TXNIP at baseline with prevalent diabetes-, hypertension-, and obesity-related phenotypes; 2) To determine the association of quantitative methylation data from ABCG1, CPT1A, and TXNIP at baseline with progression to diabetes, hypertension, and obesity over four study visits; and 3) To integrate single nucleotide polymorphism (SNP) variation, methylation marks, and gene expression data to define the most comprehensive causal model of CMS. The expected outcome of the research and training is preliminary data to inform the design of a larger study led by the applicant to assess racial/ethnic variation in the epigenetics of CMS.
Discussion: No discussion notes