Restricted Research - Award List, Note/Discussion Page
Fiscal Year: 2023
2463 The University of Texas at San Antonio (144351)
Principal Investigator: McHardy, Stanton
Total Amount of Contract, Award, or Gift (Annual before 2011): $ 53,298
Exceeds $250,000 (Is it flagged?): No
Start and End Dates: 1/1/23 - 7/1/23
Restricted Research: YES
Academic Discipline: none
Department, Center, School, or Institute: Center For Drug Discovery
Title of Contract, Award, or Gift: 4E Therapeutics Custom Synthesis and Medicinal Chemistry
Name of Granting or Contracting Agency/Entity:
4E Therapeutics, Inc.
CFDA: 0
Program Title: none
Note:
SAMs 1.1.1; The CIDD will continue to provide synthesis support to 4E Therapeutics to prepare and characterize compounds to support the program goals for their GABA-B drug discovery programs. The CIDD will execute synthesis routes to the targeted GABA-B analogs identified by 4E Therapeutics and fully characterize and deliver analogs to 4E Therapeutics for in vitro assessment. The CIDD at UTSA will execute the synthesis routes and prepare the targeted analogs, preparing 10-20 mg of each analog with a targeted purity of >96%, as assessed by 1H NMR and HPLC/MS. The CIDD will work closely with 4E Therapeutics to prepare a sufficient number of structural analogs to support the goals of the program.
Discussion: No discussion notes