Restricted Research - Award List, Note/Discussion Page
Fiscal Year: 2023
2469 The University of Texas at San Antonio (144357)
Principal Investigator: Gonzalez Porras, Maria
Total Amount of Contract, Award, or Gift (Annual before 2011): $ 50,000
Exceeds $250,000 (Is it flagged?): No
Start and End Dates: 10/1/22 - 9/30/23
Restricted Research: YES
Academic Discipline: Engineering and Integrated Design
Department, Center, School, or Institute: Ceid Biomed Eng Chem Eng
Title of Contract, Award, or Gift: The role of Acyl-CoA Synthetase Short Chain Family Member-1 (ACSS1) in the adipose tissue during cancer cachexia
Name of Granting or Contracting Agency/Entity:
University of Texas Health Science Center San Antonio
CFDA: 0
Program Title: none
Note:
SAMs 1.1.1; This research project will require the use of vertebrate animals such as mice. The mice are propagated continuously as a supply for cells and tissues for analysis. The research will perform the in vitro cell studies in Aim 1 and Aim 2. Cancer cachexia is a multifactorial metabolic syndrome that is associated with a loss of adipose tissue and skeletal muscle mass, and results in life-threatening conditions typically observed in half of untreated cancer patients. The research team will analyze the impact of disturbing fatty acid metabolism in adipose tissue during cancer cachexia. Specifically we will study the role of the Acyl-CoA Synthetase Short Chain Family Member-1 (ACSS1; an established SIRT3 deacetylation target, which is central to fatty acid oxidation (FAO) and mitochondrial bioenergetics) in adipose metabolism change during cancer cachexia. Results from these studies will provide fundamental knowledge in cachexia to generate new targeting therapies.
Discussion: No discussion notes