Restricted Research - Award List, Note/Discussion Page
Fiscal Year: 2023
2491 The University of Texas at San Antonio (144379)
Principal Investigator: McHardy,Stanton F
Total Amount of Contract, Award, or Gift (Annual before 2011): $ 41,569
Exceeds $250,000 (Is it flagged?): No
Start and End Dates: 9/1/19 - 8/31/21
Restricted Research: YES
Academic Discipline: Chemistry
Department, Center, School, or Institute: COS CHEMISTRY
Title of Contract, Award, or Gift: Validation and development of PROTACs for pediatric cancers - 167731/166293
Name of Granting or Contracting Agency/Entity:
University of Texas Health Science Center
Program Title: none
Note:
SAMs 1.1.1 The goal of the research is to begin the process of bringing resources and know-how to the GCCRI to provide PROTAC technologies to researchers who are interested in targeting “undruggable proteins, such as cancer promoting fusion proteins or their interacting partners. We will build a library of small molecules that bind E3-ligases known to work in the PROTAC paradigm. In addition, we will acquire linkers of varying chemical properties, length and flexibility. Medicinal chemistry approaches for generating linker-E3 binding small molecules will be defined and pursued. Our first candidate “war head” for developing a functional PROTAC will be MI-503, a compound which binds to Menin, a protein involved in acute leukemias. Our second candidate will be the SS18-SSX1 fusion protein involved in synovial sarcomas.
Discussion: No discussion notes