Restricted Research - Award List, Note/Discussion Page
Fiscal Year: 2023
2092 The University of Texas at Dallas (143980)
Principal Investigator: Sadler,Katelyn Elizabeth
Total Amount of Contract, Award, or Gift (Annual before 2011): $ 746,997
Exceeds $250,000 (Is it flagged?): Yes
Start and End Dates: 2/1/23 - 1/31/26
Restricted Research: YES
Academic Discipline: Neuroscience
Department, Center, School, or Institute: BBS
Title of Contract, Award, or Gift: Sickle Cell Disease Gut Dysbiosis Effects on CNS Pain Processing
Name of Granting or Contracting Agency/Entity:
Natl Institutes of Health
CFDA Link: HHS
93.839
Program Title:
none
CFDA Linked: Blood Diseases and Resources Research
Note:
This proposal will examine how the gut microbiome influences CeA activity in SCD. Data from germ-free mice show that an intact gut microbiome is critical for normal amygdala function. The gut microbiome of patients and mouse models with SCD differs from that of healthy controls (i.e. exhibit dysbiosis). Anti- or probiotic manipulation of the gut microbiome changes pain-like behaviors and CeA signaling in SCD mice.
Discussion: No discussion notes