Restricted Research - Award List, Note/Discussion Page
Fiscal Year: 2023
2495 The University of Texas at San Antonio (144383)
Principal Investigator: Wang, Yufeng
Total Amount of Contract, Award, or Gift (Annual before 2011): $ 37,971
Exceeds $250,000 (Is it flagged?): No
Start and End Dates: 1/7/21 - 11/30/22
Restricted Research: YES
Academic Discipline: Sciences
Department, Center, School, or Institute: South Texas Center for Emerging Infectious Diseases
Title of Contract, Award, or Gift: CRISPR-based RNA targeting for HIV intervention
Name of Granting or Contracting Agency/Entity:
Texas Biomedical Research Institute
Program Title: none
Note:
SAMs 1.1.1 In this research project, we will pioneer the use of the differential expression of non-coding RNAs in elite controllers to understand the role of these non-coding RNAs in HIV replication, host resistance, and disease outcomes. We propose to optimize the use of this targeting strategy against HIV and delivery to the primary cells. In the proposed project, we will carry out the optimization and efficacy of Adeno- associated virus and nanoparticle-mediated in vivo delivery of lncRNA-silencing cargo in mice and confirm its delivery using advanced imaging techniques. This approach has the potential to mediate long- term expression of a corrective payload to achieve long term function cure of HIV.
Discussion: No discussion notes